Extensive experimental studies on silica agglomerate breakup during compounding with polymer melts of various viscosities and polarities on a modular corotating twin-screw extruder were conducted. To avoid a subjectivity of the effect, due to small size contaminants involved, silica agglomerates were characterized by measuring their mass typical ideals. Increasing the screw swiftness, melt viscosity, and silica concentration were found to increase the silica agglomerate breakup. The result of these parameters on agglomerate breakup was rated the following: silica concentration > polymer viscosity screw revolutions per minute (rpm). An excellent correlation between silica agglomerate breakage and power type was also found. Based on the experimental dispersion and info method, a composite modular kinetic style for evaluating silica agglomerate breakup during compounding in a corotating twin-screw extruder was examined. The kinetic constants of breakup and reagglomeration of silica agglomerates were calculated in line with the stresses applied to the agglomerates and their cohesive strength. These constants for silica agglomerates were found to be not plastic compounding machines distinctive at high concentrations significantly. The latter was in contrast to experimental data from obtainable literature on compounding of calcium carbonate with polypropylene where the substantial reagglomeration kinetic constants of calcium carbonate in comparison to those of breakup enjoyed a major purpose in the agglomerate breakup. Assessment of the experimental and calculated outcomes on the silica agglomerate size development during compounding with polymer melts indicated an acceptable arrangement between them at great rotational speeds.